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2011•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

A Study on Pharmacokinetics of Compound Capsule of Paclitaxel in Rats

Sun Fang-di

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Abstract

Objective To study the pharmacokinetics of compound capsules of paclitaxel in rats.Methods With the commercial Taxol as the reference preparation,a pharmacokinetic study of compound capsules of paclitaxel was performed in rats.Results The pharmacokinetic parameters were as follows:t1/2 was(51.681±7.188) min and(310.076±43.086) min.AUC was(496.719±64.036) μg·min/ml and(257.385±42.385) μg·min/ml,respectively.Conclusion Compound capsules of paclitaxel can elongate the retention time of paclitaxel in rats.The absolute bioavailability of paclitaxel is 25.9% for oral administration.

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What this paper is about

Objective To study the pharmacokinetics of compound capsules of paclitaxel in rats.Methods With the commercial Taxol as the reference preparation,a pharmacokinetic study of compound capsules of paclitaxel was performed in rats.Results The pharmacokinetic parameters were as follows:t1/2 was(51.681±7.188) min and(310.076±43.086) min.AUC was(496.719±64.036) μg·min/ml and(257.385±42.385) μg·min/ml,respectively.Conclusion Compound capsules of paclitaxel can elongate the retention time of paclitaxel in rats.The absolute bioavailability of paclitaxel is 25.9% for oral administration.

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Available abstract

Objective To study the pharmacokinetics of compound capsules of paclitaxel in rats.Methods With the commercial Taxol as the reference preparation,a pharmacokinetic study of compound capsules of paclitaxel was performed in rats.Results The pharmacokinetic parameters were as follows:t1/2 was(51.681±7.188) min and(310.076±43.086) min.AUC was(496.719±64.036) μg·min/ml and(257.385±42.385) μg·min/ml,respectively.Conclusion Compound capsules of paclitaxel can elongate the retention time of paclitaxel in rats.The absolute bioavailability of paclitaxel is 25.9% for oral administration.

Key concepts: Paclitaxel, Pharmacokinetics, Capsule, Bioavailability, Pharmacology, Chemistry, Medicine, Chemotherapy

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