Association of fatty liver with body weight, serum lipid, serum glucose and insulin resistance

Objective To investigate disorder of glucose-lipid metabolism,insulin resistance in patients of fatty liver (F) and relationship between fatty liver and insulin resistance and level of tumor necrosis factor alpha(TNF-α).Methods The investigation uses case control study.Thirty-five patients of fatty liver and twenty-eight control subjects(C) were assayed for serum lipids,serum glucose(fasting and 2-hour postprandial),serum insulin(fasting and 2-hour postprandial) and serum tumour necrosis factor alpha(TNF-α).The patients of fatty liver were divided into obese and non-obese group according to diagnosis criteria.Homeostasis model assessment(HOMA) was applied for the status of insulin resistance.Results The result showed the level of fasting blood glucose(FBG),2-hour postprandial glucose(BG2h),2-hour postprandial insulin(INS2h),serum cholesterol(TC),serum triglyceride(TG),low density lipoprotein-cholesterol(LDL-C),tumor necrosis factor-α(TNF-α)and HOMA-IR were significantly increased in F of obese and non-obese compared with contol subjects(P 0.05).The levels of serum triglyceride(TG) and HOMA-IR in obese fatty liver patients were significantly higher than non-obese group(P 0.05).Logistic regression analysis showed that BG2h,TC and waist hip circumference rate(WHR) were the mainly risk factors of forming fatty liver.Multiple stepwise regression analysis showed that FBG and TG were the independent risk factors of insulin resistance in patients of fatty liver.Conclusion The present study confirms that disorder of glucose-lipid metabolism and insulin resistance were uniformly present in subjects of F,even in non-obese patients.Decreasing serum lipid,losing weight and reducing stack of interabdomen adipose tissue will benefit for decreasing liver steatosis.