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CHANGE OF Ih IN LUMBAR 4 INTACT DRG NEURONS AFTER L5 SPINAL NERVE LIGATION IN RATS

Qi Mei

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Abstract

Objective: To investigate the changes of Ih and its channel,hyperpolarization-activated cyclic nucleotide gated cation channel(HCN),in the intact lumbar 4 DRG neurons following lumbar 5(L5) spinal nerve ligation(SNL).Methods: Rat neuropathic pain model was produced by tight ligation of L5 spinal nerve and Ih was recorded with whole-cell patch clamp technique.Results: The current density and the maximal conductance of Ih in the SNL group were decreased significantly compared with those in the sham-operation control,while the reversal potential and the channel biophysics properties of HCN channel did not show any significant change.Conclusion: These electrophysiological changes of Ih and HCN channel properties in the L4 intact DRG neurons might contribute to peripheral sensitization in L5 SNL neuropathic pain.

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What this paper is about

Objective: To investigate the changes of Ih and its channel,hyperpolarization-activated cyclic nucleotide gated cation channel(HCN),in the intact lumbar 4 DRG neurons following lumbar 5(L5) spinal nerve ligation(SNL).Methods: Rat neuropathic pain model was produced by tight ligation of L5 spinal nerve and Ih was recorded with whole-cell patch clamp technique.Results: The current density and the maximal conductance of Ih in the SNL group were decreased significantly compared with those in the sham-operation control,while the reversal potential and the channel biophysics properties of HCN channel did not show any significant change.Conclusion: These electrophysiological changes of Ih and HCN channel properties in the L4 intact DRG neurons might contribute to peripheral sensitization in L5 SNL neuropathic pain.

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Available abstract

Objective: To investigate the changes of Ih and its channel,hyperpolarization-activated cyclic nucleotide gated cation channel(HCN),in the intact lumbar 4 DRG neurons following lumbar 5(L5) spinal nerve ligation(SNL).Methods: Rat neuropathic pain model was produced by tight ligation of L5 spinal nerve and Ih was recorded with whole-cell patch clamp technique.Results: The current density and the maximal conductance of Ih in the SNL group were decreased significantly compared with those in the sham-operation control,while the reversal potential and the channel biophysics properties of HCN channel did not show any significant change.Conclusion: These electrophysiological changes of Ih and HCN channel properties in the L4 intact DRG neurons might contribute to peripheral sensitization in L5 SNL neuropathic pain.

Key concepts: Medicine, Neuropathic pain, Ligation, Electrophysiology, Lumbar, Spinal nerve, Anesthesia, Patch clamp

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CHANGE OF Ih IN LUMBAR 4 INTACT DRG NEURONS AFTER L5 SPINAL NERVE LIGATION IN RATS — Research Paper | ScholarLens