Value of kidney injury molecule-1 and N-acecyl-β-D-glucosaminidase to the diagnosis of early acute kidney injury after adult heart surgery

Objective To explore the sensitivity of kidney injury molecule-1(Kim-1) and N-acecyl-β-D-glucosaminidase(NAG) in early acute kidney injury(AKI) after adult heart surgery and their clinical diagnostic value.Methods A total of 105 cases were divided into AKI group(n=65) and non-AKI group(n=40).The levels of Kim-1,NAG and serum creatinine(SCr) were detected before operation,and 24,48 and 72 hours after operation.The sensitivity of AKI markers was assessed by using ROC and AUC.Results There were no significant differences in the levels of SCr,Kim-1 and NAG between two groups before operation(P0.05).The biological markers of AKI were higher at different time points after operation in AKI group than those in non-AKI group(P0.01).The best time of combined detection of Kim-1 and NAG was by 48 hours after operation,and AUC was 0.912(95%CI:0.786 to 0.939).Conclusion The combined detection of Kim-1 and NAG can be used for early diagnosis of AKI after adult heart surgery,and has a great value to the prevention of occurrence and development of AKI.