Propofol TCI and Sevoflurane anesthesia on the effects of Cisatracurium

Objective:To investigate the neuromuscular effect of cisatracurium underpropofol Target controlled infusion (TCI) anesthesia or sevoflurane anesthesia.Methods:Forty-eight ASA classⅠorⅡgroup P,paLienls undergoing selective operations(n=24) and Sevooflurane inhalation group (group S n=24) were randomly divided into propofol TCI and sevoflurane groups(group S n=24).Methods:Forty eight patients undergoing selective surgeries were randomized into two groups.After intravenous midazoline 0.15 mg.kg-land fentanyl 4 ug.kg-1,anesthesia maintenance was achieved by sevoflurane inhalation end-tidal concentionl.7 Vol% in group S and remifentainyl(n=24),patients in group P were main- tained by propofol Target controlled and remifentainyl(n=24sinfusion).In all groups neuromusclecular was induced by rocuronium and monitored by using train-of-four(TOF) stimulation ulnar nerve.The onset time,no response time,the time recovering to 25% of control,recover index and TOF ratio(TOFr to 0.25) were recorded.Results:The no response time, the time recovering to 25% of control,recover index and TOF ratio(TOFr to 0.25) were great longer than those in propo- fol-remifentainyl group.(P0.05).But there was no difference in the onset time between the two groups.Conclusion: Propofol TCI-remifentainyl has no effect on neuromuscular of cisatracurium 1 MAC sevoflurane can potentiate the neuromus- cular of cisatracurium.