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Influence of food on bioavailability of ofloxacin

Xin Wan

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Abstract

The ofloxacin tablets 2× 100mg were administered to 9 healthy volunteers under the conditions of fasting and after meal in a cross-over time.The HPLC method was used to determine ofloxacin concentrations in serum and urine.The results showed that food had little influence on the bioavailability, but delayed the absorption rate of ofloxacin.The Parameters Tmax in fasting and postprandial were 1.1±0.3 and 2.2± 0.3h(P0.01).Cmax were 1.9± 0.4 and 1.31± 0.19 mg/ L(P0.01),AUC0-24 were13± 4 and 11.7±2.4 mg·h/ L(P0.05) and the amounts of ofloxacin excreted in urine within 24 h were 69%±6%and 67%±4%(P0.05)respectively.

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What this paper is about

The ofloxacin tablets 2× 100mg were administered to 9 healthy volunteers under the conditions of fasting and after meal in a cross-over time.The HPLC method was used to determine ofloxacin concentrations in serum and urine.The results showed that food had little influence on the bioavailability, but delayed the absorption rate of ofloxacin.The Parameters Tmax in fasting and postprandial were 1.1±0.3 and 2.2± 0.3h(P0.01).Cmax were 1.9± 0.4 and 1.31± 0.19 mg/ L(P0.01),AUC0-24 were13± 4 and 11.7±2.4 mg·h/ L(P0.05) and the amounts of ofloxacin excreted in urine within 24 h were 69%±6%and 67%±4%(P0.05)respectively.

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Available abstract

The ofloxacin tablets 2× 100mg were administered to 9 healthy volunteers under the conditions of fasting and after meal in a cross-over time.The HPLC method was used to determine ofloxacin concentrations in serum and urine.The results showed that food had little influence on the bioavailability, but delayed the absorption rate of ofloxacin.The Parameters Tmax in fasting and postprandial were 1.1±0.3 and 2.2± 0.3h(P0.01).Cmax were 1.9± 0.4 and 1.31± 0.19 mg/ L(P0.01),AUC0-24 were13± 4 and 11.7±2.4 mg·h/ L(P0.05) and the amounts of ofloxacin excreted in urine within 24 h were 69%±6%and 67%±4%(P0.05)respectively.

Key concepts: Ofloxacin, Bioavailability, Postprandial, Urine, Cmax, Chemistry, Meal, High-performance liquid chromatography

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