Clinical Study of Fructose and Sodium Chloride Injection for Treatment of Critical Illness

Objective To observe the effect of fructose and sodium chloride injection on in vivo environment in treatment of critical illness.Methods One hundred twenty critically sick patients were divided randomly into groups experiment(n=60) and control(n=60).Experimental group first used fructose and sodium chloride injection,250 ml,10ml/min,and control group 0.9% sodium chloride injection,250 ml,10 ml/min.Serum potassium,sodium,chloride,blood glucose were observed before treatment and after.Results The levels of serum potassium,sodium,chloride,blood glucose in absolute value were (0.26±0.25)mmol/L,(1.7±1.7)mmol/L,(1.5±1.3)mmol/L,(0.7±0.5)mmol/L,respectively,in experimental group,and (0.32±0.40)mmol/L,(2.7±3.1)mmol/L,(2.4±2.8)mmol/L and (0.7±0.5)mmol/L,respectively,in control.There was significant difference in levels of serum sodium,chlorine in absolute value between 2 groups before treatment and after(P0.05),but not in serum potassium and blood glucose level (P0.05).Conclusion Fructose and sodium chloride injection can maintain the stability of levels of serum potassium and blood glucose.The changes of serum sodium and chloride were less in using fructose and sodium chloride injection than in using 0.9% sodium chloride.It can provide energy for critically sick patients without causing blood glucose and serum potassium to rise,and is a safe and suitable injection.