Effects of Alanyl-Glutamine on Protection of Intestinal Dysfunction in Patients with Severe Disease

Objective:To study the effect of Alanyl-Glutamine(Aln-Gln)on preventing intestinal dysfunction in patients with severe disease. Methods: 20 seriously ill patients were divided into two groups randomizedly:therapy group (intravenous administration of Aln-Gln dipeptide;and control group (received standard therapy).Serum concentrations of glutamine(Gln),diamine oxidase(DAO) and urine lactulose/mannito(L/M)ratio were measured before and after treating. All patients’intestinal function were evaluated before and after treating as well. Results: About 85% of the patients occurred in intestinal dysfunction.Serum Gln concentration was significantly decreased in control group and increased in therapy group.Urine L/M ratio and serum concentrations of DAO were significantly increased in control group and decreased in therapy group. Conclusions: Parenterally administration of Aln-Gln dipeptide could increase the level of serum Gln, maintain the intestinal barrier and prevent intestinal dysfunction.