EVALUATION OF EARLY DIAGNOSIS VALUE OF IgM-ELISA FOR SCHISTOSOMIASIS JAPONICA

To evaluate the early diagnosis value for schistosomiasis japonica with IgM-ELISA,the antibodies specific to SEA from schistosome infected mice or acute schistosomiasis patient sera before and post-infection were detected using IgM-ELISA or IgG-ELISA.The IgM antibody increasing remarkably at day 28 post-inffection. All mice were positive of IgM antibody at day 35 post-infection with IgM-ELISA.But with IgG-ELISA all mice were positive at day 49 post-infection.All acute schistosomiasis patients' sera were positive with IgM-ELISA, but 3 acute schistomiasis patients' sera were negative with IgG-ELISA.The IgM antibody was largely more than IgG antibody before five weeks post-infection,and as more as IgG antibody within following two weeks,but less than IgG antibody after eight weeks post-infection.The results indicated that the IgM-ELISA method has a high value for early diagnosis of schistosomiasis japonica.