Expression of TPX2 in esophageal squamous carcinoma tissue

Aim:To study the expression of TPX2 and its significance in esophageal squamous cell carcinoma(ESCC) tissue.Methods:Immunohistochemical staining was used to detect the expression of TPX2 protein in 62 cases of ESCC,31 cases of adjacent atypical hyperplasia epithelium and 62 cases of normal esophageal epithelium tissue.The expression of TPX2 mRNA in 22 cases of ESCC,18 cases of adjacent atypical hyperplasia epithelium and 18 cases of normal esophageal epithelium tissue were detected using RT-PCR.Results:In ESCC,adjacent atypical hyperplasia epithelium and normal esophageal epithelium tissue,the positive rate of TPX2 protein expression was 85.5%(53/62),51.6%(16/31)and 4.8%(13/62),respectively,decreased by turn(χ2=20.037,P0.01);the positive rate of TPX2 mRNA expression was 73.3%(16/22),60.0%(12/18) and 0,respectively,decreased by turn(P0.01).The expressions of TPX2 protein and mRNA were correlated with lymph node metastasis and infiltration depth of ESCC(P0.01).Conclusion:High expression of TPX2 may be a risk factor for lymph node metastasis,and maybe a potential biomarker for early diagnosis and prognosis of ESCC.