The clinic significance of fetal Down′s syndrome.

Objective:To analysis the clinic features of pregnant women with the Down′s syndrome fetus and to discuss the prenatal screening and prenatal diagnosis methods.Methods:the clinic documents of 42 cases were reviewed,which were diagnosed by karyotype analysis.Results:20 of the 42 cases are older than 35 years old pregnancy women(elder pregnancy group),3 were detected by the ultrasound with malformation,5 of them with some abnormal signs.The other 22 case(young pregnancy group),8 of them only detected by serum screening,10 were detected by the ultrasound with malformation,2 of them with some abnormal signs.1 was low risk and no abnomal signs was detected.Totally 6 of them were not end the pregnancy,one refused to followup,1 occurred fetsl death intrauterine,3 with fetal growth restriction,1 delivered with breech presentation.Conclusions:Eleder pregnancy women need Prenatal Diagnosis;the ultrasound scan play a important role in the diagnosis of chromosome abnormal fetus,it should be done for the with abnormal fetus who want to continuous pregnancy.We should pay more attention to the pregnancy women with fetal growth restriction.