Effects of Qianliening capsule on the expression of IL-10 and TNF-α in benign prostatic hyperplasia

Objective:The purpose of this study was to study the expression of Qianliening capsule(QLNC) on interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in benign prostatic hyperplasia(BPH) in rats induced by testosterone after castration.Methods:A total of 60 rats were equally divided into six groups: Group 1 was normal group;Group 2 was model group;Group 3 served as positive control group and treated with finasteride at a dose of 0.5 mg·kg-1·d-1g.;Group 4 to Group 6 animals were administered with QLNC at dose levels of 2.25g·kg-1·d-1 and 4.5g·kg-1·d-1 and 9g·kg-1·d-1;The drugs were administered orally each day for 28 days consecutively.The prostate weight,volume,prostatic index,histopathological changes and the expressions of IL-10 and TNF-α in prostate were examinated.Results:The prostate weight,volume,prostatic index,the histopathological changes induced by testosterone after castration were significantly reduced.RT-PCR examination revealed that the expressions of IL-10 were increased and TNF-α in prostate were inhibited by QLNC treatment.Conclusion: QLNC can inhibit BPH significantly,It is one of important mechanism in treating BPH through inhibiting inflammatory factors.