2009•Journal of Jilin Institute of Chemical TechnologyRequires access
Optimization of the synthesis of 1H-1,2,4-triazole
Jian Zhang
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Abstract
1H-1,2,4-triazole was synthesized from formamide and hydrazine hydrate.The effects of reactant ratio,reaction temperature,reaction time and the choice of solvent in purification were studied in detail.The optimal reaction condition was as follows: the product was prepared from formamide and hydrazine hydrate(1/3na:nb = 1∶1.5,that was reactant ratio = 2∶1) at 185℃ for 1.5h.After washing with ethyl acetate for purification of crude product,the total yield was 82.35%,and melting point was accordant with the value referred in literatures.The structure of 1H-1,2,4-triazole had been confirmed by infrared spectrum and elemental analysis.