Expressions of B7-H4,CA_(125) and P53 in epithelial ovarian cancer and their clinical value

Objective To investigate expressions of B7-H4,CA125 and P53 in primary epithelial ovarian cancer(EOC) and to explore their relationship with prognosis.Methods Expressions of B7-H4,CA125 and P53 were determined by PV-6000 two-step immunohistochemistry in 70 cases of EOC,20 cases of normal ovarian tissues and 20 cases of benign ovarian tumors.Results The positive rate of B7H4 in epithelial ovarian cancer was 88.5%(62/70),and it was significantly higher than that in benign ovarian epithelial tumors(45%) and normal ovarian tissues (0%).The positive rate of CA125 in epithelial ovarian cancer was 77.1%,and it positively correlated with B7-H4.The positive rate of P53 in epithelial ovarian cancer was 68.6%(48/70),and was significantly lower than B7-H4(P0.05).Multivariate COX regression analysis showed that prognosis of epithelial ovarian cancer was correlated with the FIGO stage,residual tumor size,B7-H4′s positive expression,cell differentiation,CA125′s positive expression,P53′s positive expression and lymph node metastasis.Single factor Kaplan-Meier analysis showed that the intensity the B7-H4 positive expression was negatively correlated with the average survival time of patients and the cumulative five-year survival rates.Conclusion B7-H4 overexpresses in epithelial ovarian cancer and positively correlates with CA125 and is higher than P53 expression.B7-H4 is an independent risk factor of total life span of epithelial ovarian cancer patients.The stronger the B7-H4 expression,the shorter the average life time and the lower the cumulative five-year survival rate.