Resuscitation with hypertonic saline solutions in uncontrolled hemorrhagic shock

Objective: To observe the effects of hypertonic saline solutionsin in uncontrolled and controlled hemorrhagic shock.Methods: The rats were hemorrhaged(MAP=5.33kPa) for 120 minutes(controlled hemorrhagic shock),then bleeding in tail(uncontrolled hemorrhagic shock),treated in isotonic saline(0.9%NaCl) or hypertonic saline(7.5%NaCl).It were analyzed in mean arterial pressure(MAP),pulse pressure(PP),centre vein pressure(CVP) and survival times in rats.Results: MAP,PP,CVP in HS groups were significantly greater than those in NS groups and HS+UC groups,and survival times in HS groups were the longest in three groups.Conclusion: HS resuscitation in controlled hemorrhagic shock is much more effective than that of resuscitation,but in uncontrolled hemorrhagic shock may not be effective in uncontrolled hemorrhagic shock.