Clinical Analysis of 37 Cases with Primary Biliary Cirrhosis

Objective To study the clinical features of primary biliary cirrhosis(PBC) in order to facilitate cognition of the disease. Methods General status,clinical manifestations and laboratory findings and pathological features of 37 patients with PBC were reviewed. Results The most frequent symptoms were fatigue(33/37,89.18%) ,then pruritus(34/37,91.89%) and jaundice(29/37,78.37%) ,some patients(12/37,32.43%) were pruritus at early stage. The levels of serum alkailne phosphatase(ALP) and serum gamma glutamyl transpeptidase(GGT) were very high. Serum AMA-M2 was one of the most important indexes in the diagnosis of PBC. The main histopathological changes focused on small bile duct,inflammatory cell infiltrated around them,infiltration of cell was in header,different stages might be merged. Conclusion PBC is mostly found in middle-aged women. The most frequent symptoms are fatigue and pruritus,jaundice,elevated serum ALP,GGT,DBIL,GLB,CHO levels together with positive AMA-M2 can help to diagnose PBC.