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2014•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

Study on Quality Standard of Tongnao Rongshuan Capsule

Dou Jianwe

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Abstract

Objective To establish a quality standard for Tongnao Rongshuan Capsule. Methods Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae were identified by thin layer chromatography(TLC). Puerarin was determined by high performance liquid chromatography(HPLC). The HPLC system consisted of chromatographic column C18(4.6 mm×150 mm,5 μm)with methanolwater(25 ∶ 75)as the mobile phase,and the detective wave length was set at 250nm. Results Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae can be detectable by TLC. The linearity range of puerarin was 0.06784 ~0.40704 μg(r=0.9998),the average recovery was98.9 %, and RSD was 1.1 %(n =6). Conclusion The established method is simple, accurate and with good reproducibility,and can be used for the quality control of Tongnao Rongshuan Capsule.

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Objective To establish a quality standard for Tongnao Rongshuan Capsule. Methods Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae were identified by thin layer chromatography(TLC). Puerarin was determined by high performance liquid chromatography(HPLC). The HPLC system consisted of chromatographic column C18(4.6 mm×150 mm,5 μm)with methanolwater(25 ∶ 75)as the mobile phase,and the detective wave length was set at 250nm. Results Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae can be detectable by TLC. The linearity range of puerarin was 0.06784 ~0.40704 μg(r=0.9998),the average recovery was98.9 %, and RSD was 1.1 %(n =6). Conclusion The established method is simple, accurate and with good reproducibility,and can be used for the quality control of Tongnao Rongshuan Capsule.

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Available abstract

Objective To establish a quality standard for Tongnao Rongshuan Capsule. Methods Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae were identified by thin layer chromatography(TLC). Puerarin was determined by high performance liquid chromatography(HPLC). The HPLC system consisted of chromatographic column C18(4.6 mm×150 mm,5 μm)with methanolwater(25 ∶ 75)as the mobile phase,and the detective wave length was set at 250nm. Results Radix Puerariae,Radix Astragali,Caulis Spatholobi and Radix Paeoniae can be detectable by TLC. The linearity range of puerarin was 0.06784 ~0.40704 μg(r=0.9998),the average recovery was98.9 %, and RSD was 1.1 %(n =6). Conclusion The established method is simple, accurate and with good reproducibility,and can be used for the quality control of Tongnao Rongshuan Capsule.

Key concepts: Radix (gastropod), Chromatography, Puerarin, Capsule, High-performance liquid chromatography, Quality standard, Thin-layer chromatography, Chemistry

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