Clinical trial and nursing care of skin itch in uremia patients undergoing hemodialysis combined with hemoperfusion

Objective To probe the curative effect of hemodialysis( HD) combined with hemoperfusion( HP) on skin itch and nursing care in patients with uremia. Methods A total of 30 cases of uremia with skin itch were randomly assigned to hemodialysis combined with hemoperfusion group( HD + HP group,n = 15) and hemodiafiltration( HDF) combined with hemodialysis group( HDF + HD group,n = 15). 8 hours conventional HD was performed every week in all the patients. In plus, 4 hours HD + HP every week in HD + HP group and 4 hours HDF in HDF + HD group were carried out. Duration of the treatment was 12 weeks. The levels of blood urea nitrogen( BUN),serum creatinine( SCr),serum calcium,serum phosphorus( P3-) and parathyroid hormone( PTH) were measured and the status of skin itch was observed before and after treatment. Results The remission rate of skin itch in HP + HD group was 87%,it was higher than that in HDF + HD group( 67%), the difference was statistically significant( P 0. 05). Moreover,the decreases of P3-and PTH levels in HP + HD group were obvious than that in HDF + HD group( P 0. 05). But there were not statistically significant differences about the decreases of BUN and SCr levels between the two groups( P 0. 05). Conclusion HP + HD can effectively improve the skin itch in patients with uremia as compared to HDF + HD.