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Preparation of ~(188)Re-NEPTDD and its biodistribution

Wei Hongyuan

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Abstract

On the basis of first synthesizing NEPTDD (2,2,9,9-tetramethyl-4,7-diaza-4-piperidinyl-ethyl- 1,10-decanedithiol), 188 Re-NEPTDD was prepared with SnCl2 as the reducing agent. The biodistribution of 188Re-NEPTDD injected through the tail vein into normal mice and that of lipiodol solution of 188Re-NEPTDD injected through the hepatic arteries into rabbits were studied, and the whole body imaging of rabbit after injecting the lipiodol solution was performed. The results showed that liver uptake of 188Re-NEPTDD was the highest and uptakes in other organs were relatively lower.

About this research paper

What this paper is about

On the basis of first synthesizing NEPTDD (2,2,9,9-tetramethyl-4,7-diaza-4-piperidinyl-ethyl- 1,10-decanedithiol), 188 Re-NEPTDD was prepared with SnCl2 as the reducing agent. The biodistribution of 188Re-NEPTDD injected through the tail vein into normal mice and that of lipiodol solution of 188Re-NEPTDD injected through the hepatic arteries into rabbits were studied, and the whole body imaging of rabbit after injecting the lipiodol solution was performed. The results showed that liver uptake of 188Re-NEPTDD was the highest and uptakes in other organs were relatively lower.

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Available abstract

On the basis of first synthesizing NEPTDD (2,2,9,9-tetramethyl-4,7-diaza-4-piperidinyl-ethyl- 1,10-decanedithiol), 188 Re-NEPTDD was prepared with SnCl2 as the reducing agent. The biodistribution of 188Re-NEPTDD injected through the tail vein into normal mice and that of lipiodol solution of 188Re-NEPTDD injected through the hepatic arteries into rabbits were studied, and the whole body imaging of rabbit after injecting the lipiodol solution was performed. The results showed that liver uptake of 188Re-NEPTDD was the highest and uptakes in other organs were relatively lower.

Key concepts: Lipiodol, Biodistribution, Nuclear medicine, Radiochemistry, Chemistry, Tail vein, Vein, Embolization

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