THE RELATIONSHIP BETWEEN HUMAN TUMOR NECROSIS FACTOR -β(252) GENE POLYMORPHISM AND SUSCEPTIBILITY OF LUNG CANCER

[Objective]To investigate the association between polymorphisms in human tumor necrosis factor-β(252)gene and susceptibility of lung cancer.[Methods]Polymerase chain reaction-restrained fragment length polymorphism technique(PCR-RFLP)was applied to detect the single nucleotide polymorphisms(SNPs)of TNF-β+252 in 152 lung cancer patients(case group)and 127 healthy people(control group).[Results]No significant differences were found in the distribution of TNF-β+252 genotypes and allele frequencies between lung cancer patients and controls(χ2 = 0.60,P = 0.74;χ2 = 0.24,P = 0.63).After stratification analysis according to smoking,it revealed that the TNF-β+252 GG genotype in no-smokers subgroups were associated with significantly increased risk of lung cancer comparing the AA genotype(χ2 = 6.67,P = 0.04).But there was no significant difference in the distribution of A and G two alleles frequencies of TNF-β+252 GG between the case group and control group(χ2 = 1.54,P = 0.22).[Conclusion]TNF-β+252 gene polymorphism may be associated with the susceptibility of lung cancer and GG genotype may increase the risk of lung cancer among non-smoking people.