The Pathological Findings of the Bone Marrow in POEMS Syndrome

Aim:To investigate the pathological changes of the bone marrow in patients with POEMS syndrome.Methods:3 patients underwent bone marrow puncture,biopsy and immunohistochemical examination and the pathological changes were analyzed.Results:The bone marrow puncture results of 2 patients are normal and another one shows an elevation of plasma cells;the biopsy and the immunohistochemical results of all the 3 patients are abnormal.The biopsy displays a disperse or focal infiltration of mature plasma cells and plasmoblasts.The results of the immunohistochemical examination suggest a reactive plasma cell proliferation or a somewhat monoclonal(M) gammopathy.Conclusion:The pathological change of the bone marrow in POEMS syndrome is a kind of transitional expression which is between that of the normal bone marrow and the malignant lymphoma.