1995•Zhongguo yaolixue tongbaoRequires access
The antidepressant effect of domestic moclobemide
Wei Zhao
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Abstract
The effects of domestic moclobemide on animal model of depressant and monoamine oxidase type A(MAO-A) activity were studied. 5～20mg· kg-1 ig moclobemide prevented dose-dependently blepharoptosis induced by reserpine(2.8mg·kg-1, sc) rat. 5￣25mg·kg-1(ig)moclobemide significantly decreased the duration of immobility in dispair test mouse. Domestic moclobemide dose 6～24 mg·kg-1(ig) demonstrated dose-dependent inhibitory effect on MAO-A activity mouse brain tissues. When the mice were orally given moclobemide 24 mg· kg-1(ig),the moclobemide induced maximum MAOA inhibition by 74.4% 2 h after drug treatment, and the enzyme activity had almost recovered completely by 16 h.