Comparison of the overall distribution of metastatic bony lesions in prostate carcinoma,breast carcinoma and lung carcinoma

Objective To explore the features of bone metastases in prostate carcinoma,breast carcinoma and lung carcinoma.Methods Bone imaging with 99mTc-methylene diphosphonate was performed in 144 patients with prostate carcinoma,360 patients with breast carcinoma and 460 patients with lung carcinoma which were confirmed by pathological methods.The distribution of metastatic bony lesions in different tumors was studied.Results(1)The incidence of bone metastasis of patients with prostate carcinoma was significantly higher than that of patients with breast carcinoma[70.8%(102/144) vs.41.7%(150/360),χ2=35.8,P=0.000]and that of patients with lung carcinoma[56.1%(258/460),χ2=10.2,P=0.001].(2)The proportion of metastatic pelvic lesions in prostate carcinoma was significantly higher than that in breast carcinoma[28.6%(572/2000) vs.19.8%(262/1324),χ2=33.6,P=0.000]and that in lung carcinoma[21.8%(496/2279),χ2=26.5,P=0.000].The difference of the metastatic vertebral lesion proportions in prostate carcinoma,breast carcinoma and lung carcinoma was not statistically significant(χ2=0.552,υ=2,P=0.759).(3)In these tumors,the differences of the metastatic lesion proportions in cervical vertebrae,thoracic vertebrae,lumbar vertebrae,sacrococcyx,collarbone,humerus,thigh-bone,and the middle and distal extremities were not statistically significant(P0.05).Whereas,the proportions of metastatic iliac,ischiac and pubic lesions in prostate carcinoma were bigger than that in breast carcinoma and that in lung carcinoma(P0.05),the proportions of metastatic cranioaural and sternal lesions in breast carcinoma were bigger than that in prostate carcinoma and that in lung carcinoma(P0.05),and the proportions of metastatic costal and scapular lesions in lung carcinoma were bigger than that in prostate carcinoma and that in breast carcinoma(P0.05).Conclusions The distribution of bone metastases in prostate carcinoma,breast carcinoma and lung carcinoma presents not only same features but also different characteristics.Understanding these features is helpful for the diagnosis and differential diagnosis of diseases.