Effects of losartan on the left ventricular remodeling following acute myocardial infarction

Objective: To compare the inhibitory effects of losartan on left ventricular remodeling (LVRM) after acute myocardial infarction (AMI).Methods: A total of 62 patients with AMI were entered into the study.31 patients were randomized to conventional treatment group,31 patients to losatran treatment group.At 2nd week,and 24th week after AMI,the left ventricular myocardium weight were measured by echocardiogram,and the parameters of left ventricular systolic and diastolic function were measured by equilibrium radionuclide angiography.Results: At 24th week,IVST,LVPWT,LVDd and LVMI in losartan treatment group were significantly decreased as compared with conventional treatmnet group.At 24th week,LVEF and LPFR in losartan treament group were significantly increased ( P 0 01) as compared with those in conventional treatment group,respectively.LTPER and LTPFR in losartan group were decreased as compared with the conventional treatment group,respectively.Conclusion: losartan might significantly reduce myocardial hypertrophy and LVRM following AMI.Losartan improve the left ventricular systolic function.