Clinical and Pathological Analysis of Lipid Storage Myopathy (Report of 15 Cases)

Objective To study 15 cases of lipid storage myopathy(LSM) and to analyze them in clinical and pathological features. Methods The clinical data of 15 cases were collected and muscle biopsies were done with routine and histochemical staining. Light and electron microscopic studies were made. Results The clinical characters of all patients were progressive muscle weakness with increased muscle enzymes in the plasma. The light and electron microscopic studies of muscle biopsy materials showed excessive amounts of fatty droplets in muscle fibers. Type I muscle fibers are more severely affected by the storage of the fat. Conclusion Fatigue and muscle weakness especially in proximal muscle were prominent symptoms in LSM. Muscle biopsy has a significant value for the definite diagnosis of this disease. LSM can be treated by corticosteroid. \;