Research of inflammatory factors and Th17 and Treg cell ratio of different stages of elderly patients with COPD

Objective To investigate the inflammatory factors and Th17 and Treg cell ratio of different stages of elderly patients with COPD. Methods The study selected 68 COPD patients as the observation group,including32 stable COPD patients and 36 AECOPD patients,and 30 healthy people as the control group. The ratio of CD+4Th17 and CD+4CD+25Treg cells was detected by flow cytometry,and the levels of IL-6,IL-10,IL-17,IL-21,IL-22 and TGF-β were detected by ELISA. Results The levels of FEV1 and FEV1/ FVC were the lowest in the AECOPD group,followed by the stable COPD group and the control group( P 0. 05). The ratio of CD+4Th17 cells was higher and the ratio of CD+4CD+25Treg cells was lower in the AECOPD group than in the stable group and the control group( P 0. 05). The levels of IL-6,IL-17,IL-21 and IL-22 were higher and the levels of IL-10 and TGF-β were lower in the AECOPD group than in the stable group and the control group( P 0. 05). The level of FEV1 was negatively correlated with IL-6,IL-17,IL-21 and IL-22,and it was positively correlated with IL-10 and TGF-β. The value of FEV1/ FVC was negatively correlated with IL-6,IL-17,IL-21 and IL-22,and it was negatively correlated with IL-10 and TGF-β. Conclusion The imbalance of Th17 / Treg can cause the body to generate an increase in pro-inflammatory cytokines,leading to respiratory dysfunction in COPD patients and making their situation worsen.