Meaning of soluble triggering receptor expressed on myeloid cells- 1 in diagnosis of community acquired pneumonia

Objective To investigate the meaning of soluble triggering receptor expressed on myeloid cells-1( sTREM-1) in the diagnosis of community acquired pneumonia( CAP). Methods Serum sTREM- 1,CRP,Fbg,D- Dimer were determined in sixty patients with community acquired pneumonia and twenty- four healthy volunteers controls. CAP group patients were divided into non- severe pneumonia group( 44 cases) and severe pneumonia group( 16 cases) by IDSA /ATS severe CAP criteria,divided into mild mid range pneumonia group( 50 cases) and grossly pneumonia group( 10 cases) by CURB- 65 criteria,divided into low risk pneumonia group( 42 cases) and high risk pneumonia group( 18 cases)by PSI score. Results Level of serum sTREM- 1 was significant higher in pneumonia group than in the normal control group. Level of serum CRP,Fbg,D- Dimer were higher in pneumonia group than in the normal control group,too. Level of serum sTREM- 1 was higher in severe pneumonia group than in non- severe pneumonia group [( 122. 34 ± 24. 14) ng /L vs( 44. 74 ± 9. 22) ng / L,P 0. 05]. Level of serum sTREM- 1 was higher in grossly pneumonia group than in mild midrange pneumonia group [( 120. 21 ± 39. 24) ng / L vs( 54. 48 ± 9. 87) ng / L,P 0. 05]. Level of serum sTREM- 1was higher in high risk pneumonia group than in low risk pneumonia group [( 126. 06 ± 21. 23) ng / L vs( 39. 45 ± 8. 08)ng / L,P 0. 05]. For ROC curve in diagnosis of CAP,when the cut- off value of sTREM- 1 was set at 15. 79 ng / L,the sensitivity was 63. 30%,specificity was 83. 30%,accuracy was 71. 40%. Conclusion Serum sTREM- 1 level is higher in CAP. Detection of serum sTREM- 1 is helpful in the diagnosis of CAP. Serum sTREM- 1 level could help to evaluate the severity of infection.