The Preparation of D-4-Hydroxyphenylglycine

DL-p-Hydroxyphenylglycine was synthesized from phenol and glyoxylic acid and converted into its methyl ester by reaction with SOCl2 and methanol.After treatment with(+)-tartaric acid,the methyl D-p hydroxyphenylglycinate(+)-tartrate was obtained.The tartrate was hydrolyzed in alkaline solution and then neutralized to form the D-hydroxyphenylglycine.The L-hydroxyphenylglycine was racemized in methanol with salicylaldehyde.The resolution yield was up to 70.7% with 99.8%e.e.