2007•Zhongguo yaowu huaxue zazhiRequires access
Research progress of PARP inhibitors on neuro-protection
Fengchao Jiang
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Abstract
The poly(ADP-ribose)polymerase(PARP),a nuclear enzyme relative to DNA repair,is a mediator of cell death by ATP depletion.Thus the PARP inhibitor was considered as a novel neuro-protectant.A study about structure and biological activity of PARP was introduced in this review,and emphasis was placed on both the neuro-protective function and the structureactivity relationship of the PARP inhibitors reported in recent years.