The clinical application value of glycosylated hemoglobin (HbA_1c) plus fasting plasma glucose in diagnosing diabetes

Objective To evaluate clinical application value of HbA1c plus fasting plasma glucose(FPG) in diagnosing diabetes mellitus(DM).Methods 681 patients with DM were from Shiyan.The level of HbA1c by Bio-RAD-10 glycated hemoglobin analyzer,FPG by OLYMPUS AU-5400 automatic biochemistry analyzer.The final diagnosis was made by OGTT.Results In 681 outpatients simultaneously receiving determination of HbA1c and FPG,114 cases were diagnosed as diabetes.26 of 30 cases with normal FPG but abnormal HbA1c were eventually proved to be type 1 diabetes,88 of 92 with both abnormal HbA1c and FPG were proved to be type 2 diabetes.In 24 cases with abnormal FPG but normal HbA1c,3 were diagnosed as impaired fasting glucose,2 were diagnosed as IGT.And among 6 cases with normal FPG and abnormal HbA1c,3 were diagnosed as IGT.Conclusions The simultaneous determination of HbA1c and FPG can improve the specificity and sensitivity in screening and diagnosing diabetes mellitus.And it can improve early diagnostic rates of impaired glucose tolerance and type 2 diabetes.