2002•Academic Journal of Guangzhou Medical CollegeRequires access

Effect of Tetramethylpyrazine on Apoptosis of Retinal Cells after Retinal Ischemia in Rats

Jinxing Li

Abstract

Objective:To investigate the effect of Tetramethylpyrazine on apoptosis after transient retinal ischemia. Methods: A model of retinal ischemia was established by injecting saline into the anterior chamber of SD rats. Tetramethylpyrazine was given peritoneally in the treatment group once daily. The retinal apoptosis cells were detected by terminal - deoxynucleotidyl transferase mediated nick end labeling ( Tunel) . Results: The number of apoptosis cells in ischemia group were significantly higher than that of the treatment group, there was significant difference between two groups at each time-point. ConclusionTetramethylpyrazine has the protective effect against apoptosis in ischemic retina.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Tetramethylpyrazine, TUNEL assay, Apoptosis, Retinal, Ischemia, Terminal deoxynucleotidyl transferase, Retina, Saline