Effect of hypothermia treatment for severe craniocerebral injured Patients

Objective To analyze the effect and mechanism of hypothermia(HT) treatment for severe craniocerebral injury. Methods 32 cases were treated with moderate HT group and 28 cases with normal temperature (control group), lntracranial pressure(ICP), cranial perfusion pressure(CPP), brain electrical activity map(BEAM), serum NSE, transcranial ultrasonic Doppler (TCD) findings and prognosis (GCS) were observed both before and after moderate hypothermia treatment. Results In the treatment group, ICP, CCP, BEAM and outcome were improved after HT treatment with a significant difference compared with the control group. After hypothermia treatment, the average level of serum NSE in the treatment group was reduced from 125.3±21.4ng/L to 70.5±20.8 ng/L (p0.01). Records of MCA mean velocity (Vm) were reduced from 65.1±4.9cm/s to 52.7±4.3 cm/s (P 0.01). A decrease was seen in MCA systolic velocity (Vs) and pulse index (PI) value with a significant difference(P0.01). Conclusions HT treatment can decrease ICP, increase CCP and improve the clinical manifestation, BEAM and outcome of severe craniocerebral injured patients improving the blood velocity of MCA and decreasing cerebral vascular resistance. HT treatment can reduce cerebral vascular spasms, cerebral ischemia and hypoxia.