Study on the Serum Levels of MMP-2 and the Number of Leukocytes in Peripheral Blood of Different Types Cerebral Infarction

Objective:This dynamic study on the relationship among the serum levels of matrix metalloproteinase-2(MMP-2),the number of leukocytes in peripheral blood,the volume of infarction,degree of neurofunction impairment and prognosis in patients with acute cerebral infarction,and investigate the effect of MMP-2,WBC in cerebral infarction.Methods: We measured the MMP-2 lever of 48 cases acute cerebral infarction patients brought into by enzyme linked immunosorbent assay within 48 hours,the 7th days,the 14 th days after onset and measured the number of leukocytes in peripheral blood in the same time,and compared with the control group.Results: The serum lever of MMP-2 and number of leukocytes in peripheral blood of cerebral infarction group was obviously higher than control group.MMP-2 is highest in the 7th days(P0.05),WBC is highest within 48 hours after onset(P0.05),they have obviously positive correlation between the volume of infarction and the degree of neurofunction impairment and negative correlation with prognosis.Both of them are positive linear correlation(r=0.628,P0.05).Conclusions:Inflammatory reaction associated with the acute cerebral infarction,took place in the process of ischemic brain damage.MMP-2 and Leukocyte take on important role in the process,and both of them were positive correlated.