Comparison between Aspirin Combined with Dipyridamole versus Aspirin Alone after Acute Ischemic Stroke Event for Prevention of Erebrovascular Ischemic Event

Objectives: To compare the effect of aspirin plus extended-release dipyridamole versus aspirin alone in acute intervention treatment after acute ischemic stoke. Methods: 60 ischemic stroke patients within 48 hours were randomized to aspirin (50mg/d twice a day) or combination (aspirin 50mg/d+ extended-release dipyridamole 100 mg/d twice a day) and followed up for 6 months. Incidence of ischemic cerebrovascular events and reduction of NIHSS score lower value were compared, and side effects were recorded. Results There were 25 patients in the aspirin group and 26 patients in the combination group after 6 months follow-up. Incidence of erebrovascular ischemic event in the combination group within 6 months was significantly lower than that of aspirin alone group (11.5% vs. 20.0%, P 0.05). Moreover, NIHSS score in the combination group reduce even more obviously than that in aspirin alone group (4.52 ± 1.8 vs 3.62 ±3.3, P0.05). Conclusions: This study showed more efficacy of combination group than aspirin alone in acute intervention treatment for prevention of erebrovascular ischemic event within 6 months.