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2008•Journal of Oral and Maxillofacial SurgeryRequires access

Experimental Study on Biocompatibility of a Novel Bone Substitute-Mesoporous Bioactive Glass

Jianbin Li, Yi Wang, Chengzhong Yu, Yuanliang Huang, Lina Sui

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Abstract

Objective:To investigate the biocompatibility of a novel bioactive glass(mesoporous bioactive glass,MBG)in vitro,and the probability of MBG to be a bone substitute.Methods:Osteoblasts of SD rats were divided into 2 groups. Experiment osteoblasts were seeded onto MBG,and control osteoblasts was cultured alone.Cell proliferation and ALP activity of osteoblasts were measured,and observed by the scanning electron microscopy(SEM).Results:Significant differences appeared in proliferation and ALP activity between experiment group and control group.Ceils adhered to the surface of MBG at the 1st day,and became a confluent layer and excreted matrix on bone-substitute at the 4th day. Conclusion:MBG is well in biocompatibility and may be an outstanding bone-substitute.

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What this paper is about

Objective:To investigate the biocompatibility of a novel bioactive glass(mesoporous bioactive glass,MBG)in vitro,and the probability of MBG to be a bone substitute.Methods:Osteoblasts of SD rats were divided into 2 groups. Experiment osteoblasts were seeded onto MBG,and control osteoblasts was cultured alone.Cell proliferation and ALP activity of osteoblasts were measured,and observed by the scanning electron microscopy(SEM).Results:Significant differences appeared in proliferation and ALP activity between experiment group and control group.Ceils adhered to the surface of MBG at the 1st day,and became a confluent layer and excreted matrix on bone-substitute at the 4th day. Conclusion:MBG is well in biocompatibility and may be an outstanding bone-substitute.

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Available abstract

Objective:To investigate the biocompatibility of a novel bioactive glass(mesoporous bioactive glass,MBG)in vitro,and the probability of MBG to be a bone substitute.Methods:Osteoblasts of SD rats were divided into 2 groups. Experiment osteoblasts were seeded onto MBG,and control osteoblasts was cultured alone.Cell proliferation and ALP activity of osteoblasts were measured,and observed by the scanning electron microscopy(SEM).Results:Significant differences appeared in proliferation and ALP activity between experiment group and control group.Ceils adhered to the surface of MBG at the 1st day,and became a confluent layer and excreted matrix on bone-substitute at the 4th day. Conclusion:MBG is well in biocompatibility and may be an outstanding bone-substitute.

Key concepts: Biocompatibility, Bioactive glass, Medicine, Osteoblast, Biomedical engineering, Mesoporous material, Scanning electron microscope, Bone cell

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