DYNAMIC OXYGENATED MONITORING ON NEONATES WITH RESPIRATORY FAILURE TREATED WITH HIGN FREQUENCY OSCILLATORY MECHANICAL VENTILATION

Objective To investigate changes of dynamic oxygenation parameters(DOP) within 24 hours and assess its value in predicting the prognosis in neonates with respiratory failure treated with high frequency oscillatory mechanical ventilation(HFOV).Methods Data of 43 neonates with respiratory failure treated with HFOV-in NICU of Qingdao Women and Children Hospital were collected.The pH value of blood,partial pressure of oxygen(PaO2) and carbon dioxide(PaCO2),mean airway pressure(MAP),and fraction of inspired oxygen(FiO2) at 0,2,6,12 and 24 hours after using HFOV were respectively recorded,and ratio of alveolar oxygen partial pressure and PaO2 in artery(a/A),oxygenation index(OI),alveolar-arterial oxygen partial pressure difference(A-aDO2) at each time were calculated,and respiratory distress at 0,6 and 12 hours was scored.Results In survival group,after 2 h of HFOV treatment,the differences of PaO2,PaCO2,OI,A-aDO2,MAP,and FiO2 were significant as compared with that before treatment(t=-5.90-6.85,P0.05),and PaO2,PaCO2,blood pH,a/A,OI,A-aDO2,MAP,and FiO2 were all improved at 6,12,and 24 h versus before HFOV(t=-10.30-9.73,P0.05).In the death group,though the above parameters showed somewhat improvements,the differences were not significant as compared with that before treatment(P0.05).As for respiratory distress scores,the differences between before and after therapy in survival group were significant(t=10.82,14.51;P0.01),but not in the death group(P0.05).Conclusion Monitoring the 24-hour DOP in neonates with respiratory failure treated with HFOV may help predict its prognosis.