Distribution of Hepatitis B Virus Genotype and Clinical Significance in Shandong Province

[Objective]To explore the distribution of Hepatitis B virus(HBV) Genotype in Shandong Province and the clinical,virological features of the patients infected with different HBV genotype.[Methods]The HBV Genotype,Pre C and Basal core promoter(BCP) mutations of 128 chronic HBV infected patients were detected using PCR-RFLP methods.[Results]The prevalence rate of HBV genotype C(104) and Genotype B(22)in Shandong Province was 81.25% and 17.19% respectively.No other Genotype was detected.[Conclusion]HBV Genotype C is the predominant Genotype in Shandong Province.There exists clinical and virological difference between patients infected with HBV genotype B and C.The prevalence rate of HBV genotype C in chronic HBV carrier is lower than those in chronic Hepatitis B,cirrhosis and hepatocellular carcinoma patients.The age of patients infected with HBV Genotype B is younger than those infected with Genotype C.The HBeAg positive rate,HBV DNA level and BCP mutation rate in Genotype C is higher than that in Genotype B.It was suggested that HBeAg seroconversion can be easily detected in Genotype B,Genotype C which had high level of HBV duplication can result to repeated inflammation in the liver.The clinical feature was based on virological characteristic of different HBV genotypes.