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2000•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Study on the Mechanism of Matrine on Hepatic Fibrosis in vitro

Hu Jin

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Abstract

Aim To study the mechanism of matrine on hepatic fibrosis by the inhibition of proliferation of HSC-T6, synthesis of collagen and hyaluronic acid.Methods The effects of matrine on proliferation of HSC-T6 were observed by MTT colorimetric assay,synthesis of collagen was observed by the incorporation of 3 H-proline, synthesis of hyaluronic was detected by radioimmunoassay.Results Matrine inhibited the proliferation of HSC-T6,synthesis of collagen and hyaluronic acid in dose-dependent manner.Conclusion Matrine inhibited hepatic fibrosis by inhibition of HSC-T6 cell proliferation, collagen synthesis and hyaluronic acid synthesis significantly in vitro.

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What this paper is about

Aim To study the mechanism of matrine on hepatic fibrosis by the inhibition of proliferation of HSC-T6, synthesis of collagen and hyaluronic acid.Methods The effects of matrine on proliferation of HSC-T6 were observed by MTT colorimetric assay,synthesis of collagen was observed by the incorporation of 3 H-proline, synthesis of hyaluronic was detected by radioimmunoassay.Results Matrine inhibited the proliferation of HSC-T6,synthesis of collagen and hyaluronic acid in dose-dependent manner.Conclusion Matrine inhibited hepatic fibrosis by inhibition of HSC-T6 cell proliferation, collagen synthesis and hyaluronic acid synthesis significantly in vitro.

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Available abstract

Aim To study the mechanism of matrine on hepatic fibrosis by the inhibition of proliferation of HSC-T6, synthesis of collagen and hyaluronic acid.Methods The effects of matrine on proliferation of HSC-T6 were observed by MTT colorimetric assay,synthesis of collagen was observed by the incorporation of 3 H-proline, synthesis of hyaluronic was detected by radioimmunoassay.Results Matrine inhibited the proliferation of HSC-T6,synthesis of collagen and hyaluronic acid in dose-dependent manner.Conclusion Matrine inhibited hepatic fibrosis by inhibition of HSC-T6 cell proliferation, collagen synthesis and hyaluronic acid synthesis significantly in vitro.

Key concepts: Matrine, Hyaluronic acid, In vitro, Chemistry, Type I collagen, MTT assay, Pharmacology, Hepatic fibrosis

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