Diagnosis of central neurocytoma by MRI:a report of 9 cases

Objective To study the clinical significance of MR imagings features in the diagnosis on central neurocytoma( CNC).Methods From January 2010 to December 2012,9 patients with CNC were analyzed and examined by MRI before surgery,then received postoperative pathology examination.Results CNC were in the left lateral ventricle of 9 patients,closely linked with the Monro hole,of which 4 cases were in the first 2 /3 of central ventricle of the left lateral ventricle,3 cases in the septum pellucidum and growth to bilateral ventricles,2 cases of infiltrating in the septum pellucidum and base side adhesion.For CNC,MRI signal was not uniform,solid part T1WI showed equal or slightly low signal,multiple cysts and signal cord like structure with the ventricular wall and septum pellucidum adhesion.By contrast-enhanced CT scan,there were the solid part heterogeneous obvious enhancement in 4 cases,moderate and slight uneven enhancement in 3 cases and 2 cases respectively.Uniform size,round or oval cells were showed by HE staining,and the synaptophysin was positive in 6 cases by immunohistochemical staining,positive expression of glial fibrillary acidic protein in 3 cases.After operation,3 patients were lost to follow up,for 6 cases were followed up,survival of 2 cases in 3 years,4 cases in 2 years.Conclusion The results suggest that MRI display is located near the lateral ventricle central Monro hole before and lesions suggestive of CNC in young patients.For most CNC,synaptophysin has positive expression by immunohistochemical staining.