The Correlation Study between Vascular Dementia and NF155

Objective:To investigate the correlation between vascular dementia by chronic ischemia and NF155. Method:40 male wistar rats were randomly divided into model group of 24 cases and the control group of 12 cases from December 2013 to May 2014.Rats in the model group were treated with permanent bilateral carotid artery ligation(2VO) to prepare chronic forebrain ischemia induced animal model of vascular dementia, and the rats in the control group just treated surgery.Morris water maze was given in each group before and after operation to measure the data of memory behavior,than compared the different escape latency between groups before and after operation to make it clear whether the rats in model group dementia.The brain of rats were made into homogenate, than ELISA was given to measure the NF155 expression of every group. Result:There were no significant differences between the model group and the sham control group before modeling(P0.05).After modeling, the escape latency of 30 days after surgery group were significantly longer than the sham control group in the sixth day(t=2.667,6.812,8.743,10.775;P=0.014,0.000,0.000,0.000);60 days after surgery group were significantly longer than the sham group in the fifth day(t=3.016,4.137,7.562,7.910,12.686;P=0.006,0.000,0.000,0.000,0.000).The NF155 concentration of model 30 days group and model 60 days group detected by ELISA was respectively(48.27±7.32)ng/m L and(37.65±6.88)ng/m L. Compared with the sham control group(85.07±6.75)ng/m L,the differences were statistically significant(P0.05).This revealed that the NF155 content in the rats brain of model group significantly decreased compared with the sham control group. Conclusion:The change of NF155 content in brain may be involve in the occurrence of vascular dementia induced by chronic ischemia.