Effect of Carvedilol on the Levels of Endothelin and Nitric Oxide after Percutaneous Transluminal Coronary Angioplasty

Aim To understand the effect of carvedilol on the coronary vascular endothelial function of the patients with coronary heart disease after percutaneous transluminal coronary angioplasty (PTCA). Methods 51 cases,having one or more than two branches narrow (≥70%),were diagnosed by coronary angiography. These patients were divided randomly into carvedilol group (n=28) and control group (n=23) who did not take carvedilol. Endothelin (ET) and nitric oxide (NO) levels of peripheral blood were measured before and after PTCA,before and after two week by taking carvedilol. Results Compared with the ET (carvedilol group: 70.6±12.8 μg/L,control group: 71.5±13.3 μg/L) and NO (carvedilol group: 50.3±13.4 μmol/L,control group: 50.9±12.6 μmol/L) levels before PTCA,ET (carvedilol group: 84.9±14.7 μg/L,control group: 85.6±15.4 μg/L) were markedly increased and NO (carvedilol group: 50.3±13.4 μmol/L,control group: 50.9±12.6 μmol/L) were decreased after PTCA (P0.05); compared with the ET (84.4±14.9 μg/L) and NO (51.6±12.5 μmol/L) levels before taking carvedilol,ET (74.6±15.6 μg/L) were decreased and NO (62.7±12.8 μmol/L)were increased after two weeks (P0.05),but the ET and NO levels of the control group did not change in the period of two-week observation (P0.05). Conclusion Carvedilol may improve the coronary vascular endothelial function after PTCA.