ScholarLens Back to search
2005•Journal of OncologyRequires access

Expression of p21~(WAF1) and p16 in Primary Hepatocellular Carcinoma and its Clinical Significance

Jiansheng Luo

Open publisher page 0 citations

Abstract

Purpose] To investigate the relationship between p21WAF1 and p16 expressions in hepatocellular carcinoma(HCC) and their significance. [Methods] Expression of p21WAF1 and p16 was detected by immunohistochemical staining in 74 cases with HCC. [Results] Positive rates of p16 were 51.35% in HCC and 100% in normal liver tissues. Positive rates of p21WAF1 were 43.24% in HCCs and 100% in normal livers. The expressions of p21WAF1 and p16 in HCC were lower than those in normal liver specimen(P0.05). The positive rate of p16 was 23.08% in HCCs with metastasis. It was significantly lower than that in HCCs without metastasis(71.43%,P0.05). [Conclusion] The deletion of p16 protein and p21WAF1 protein related to hepatocarcinogenesis, p16 negative HCCs associated with metastasis.

About this research paper

What this paper is about

Purpose] To investigate the relationship between p21WAF1 and p16 expressions in hepatocellular carcinoma(HCC) and their significance. [Methods] Expression of p21WAF1 and p16 was detected by immunohistochemical staining in 74 cases with HCC. [Results] Positive rates of p16 were 51.35% in HCC and 100% in normal liver tissues. Positive rates of p21WAF1 were 43.24% in HCCs and 100% in normal livers. The expressions of p21WAF1 and p16 in HCC were lower than those in normal liver specimen(P0.05). The positive rate of p16 was 23.08% in HCCs with metastasis. It was significantly lower than that in HCCs without metastasis(71.43%,P0.05). [Conclusion] The deletion of p16 protein and p21WAF1 protein related to hepatocarcinogenesis, p16 negative HCCs associated with metastasis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Purpose] To investigate the relationship between p21WAF1 and p16 expressions in hepatocellular carcinoma(HCC) and their significance. [Methods] Expression of p21WAF1 and p16 was detected by immunohistochemical staining in 74 cases with HCC. [Results] Positive rates of p16 were 51.35% in HCC and 100% in normal liver tissues. Positive rates of p21WAF1 were 43.24% in HCCs and 100% in normal livers. The expressions of p21WAF1 and p16 in HCC were lower than those in normal liver specimen(P0.05). The positive rate of p16 was 23.08% in HCCs with metastasis. It was significantly lower than that in HCCs without metastasis(71.43%,P0.05). [Conclusion] The deletion of p16 protein and p21WAF1 protein related to hepatocarcinogenesis, p16 negative HCCs associated with metastasis.

Key concepts: HCCS, Hepatocellular carcinoma, Medicine, Immunohistochemistry, Metastasis, Clinical significance, Pathology, Staining

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of p21~(WAF1) and p16 in Primary Hepatocellular Carcinoma and its Clinical Significance — Research Paper | ScholarLens