Study of Protective Effect of Pentoxifylline (PTX)on Acute Cerebral Ischemia in Mice

Objective To study the effect of pentoxifylline(PTX)on brain function in acute cerebral ischemia mice.Methods Cerebral ischemia was induced by cutting head and ligating bilateral carotid arteries completely or incompletely.The nerve symptom,survival time and the change of brain cell in mice were observed during the acute cerebral ischemia and the protective effect of PTX on acute cerebral ischemia mice was evaluated.Results The stroke index score and the percentage of denaturation or necrosis of brain cell in the ischemic mice were obviously reduced by PTX at dose of 25 and 50 mg·kg -1 .The persistent time of gasping of mice by decapitation and survival time of mice by bilateral carotid arteries ligation were obviously prolonged by the same dose of PTX.Conclusion PTX has a protective effect on acute cerebral ischemia mice.