EFFECTS OF SOYBEAN PEPTIDES ON BLOOD LIPIDS IN HYPERLIPIDEMIA RATS

To observe the effects of soybean peptides on regulation of liquid metabolism,hemo- rheological indexes,antioxidation in rats with hyperlipidemia.Sixty-three SD rats were randomly divided into seven groups as normal control group,model control group,Xuezhikang(100 mg kg~(-1) d~(-1),i.p.)group,soybean peptide(400 mg kg~(-1) d~(-1),i.g.)group,soybean peptide(800 mg kg~(-1) d~(-1),i.g.)group,soybean peptide(100 mg kg~(-1) d~(-1),i.p.)group and soybean peptide(400 mg kg~(-1) d~(-1),i.p.)group.All rats were fed with high-lipid forage except normal control group.Soybean peptides were administered continually for 30 days and blood was collected to de- tect TC、TG and HDL-C in serum once every two weeks and the levels of serum SOD、MDA and NO were assayed at the last day.Results showed that soybean peptides could significantly de- crease TC、TG and LDL-C levels in experimental hyperlipidemia rats(P0.05),but it had no sig- nificant effect on the level of HDL-C(P0.05).The activity of SOD in rats of soybean peptides administered groups were much higher than those of model control group(P0.05).Meanwhile, the MDA and NO levels in rats of soybean peptides administered groups were much lower than those of model control group(P0.05).The results suggested that the Soybean Peptides can regulate the liquid metabolism,improve hemorheological indexes,increase the activity of scaven- ging free radicals in rats with hyperlipidemia.