Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88,TLR4 Receptor

Objective:To observe the therapeutic effects of astragalus saponin on rats with atrophic gastritis(CAG),and on myeloid differentiation factor 88(MyD88),Toll-like receptor 4(TLR4) receptor.Method:The rat model of atrophic gastritis was established with synthesis method.Then saline,astragalus saponin(14.93 mg·kg-1) and sucralfate(360 mg·kg-1)were given orally after the modeling rats were sacrificed after 10 weeks and 15 weeks,and whole stomach was collected to observe whether there were intestinal metaplasia,pseudo-pyloric metaplasia,atypical hyperplasia under the microscope,the expression of MyD88 and TLR4 was detected.Result: Astragalus saponin had a therapeutic effect on rats with atrophic gastritis,the occurrence of intestinal metaplasia,pseudo-pyloric metaplasia,atypical hyperplasia significantly reduced,at the same time,the expression of TLR4 and MyD88 decreased significantly compared with blank group and sucralfate group,higher expression of superoxide dismutase(SOD) activity in astragalus saponin group was found.Conclusion: Astragalus saponin can prevent the activation of MyD88,TLR4 receptors and improve the activity of SOD,it has a therapeutic effect on atrophic gastritis.