Change of Endothelin in Chronic Gradual Spinal Cord Injury after Decompression and Relation with Neuronal Function Recovery

Objective:To reseach the changes of endothelin in chronic gradual spinal cord injury after decompression and relation with neuronal function recovery in rats.Method: Experimental rats were divided into eleven groops in random:normal group,chronic gradual spinal cord injury group,chronic gradual spinal cord injury+decompression 1,2,3,5,7,10,14,20,28 day groups.ET level in spinal cord were measured by radioimmunoassay.Neuronal function was evaluated by open field and inclined plane tests Result:After decompression,concentrations of ET in spinal cord significantly decreased,after 7 days,it decreased 10 6% than that in chronic spinal cord injury groups,afterwards,it decreased slowly and maintained a lower level.Neuronal function recovered faster 10 days after decompression,afterwards,it recovered slowly.Conclusion:After chronic gradual spinal cord injury decompression,concentrations of ET in spinal cord significantly decreases,and which have relations with neuronal functional recovery of spinal cord.