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Chemical Constituents of Aeschynanthus superbus Clarke

Wenyi Kang

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Abstract

OBJECTIVE To study the chemical constituents of Aeschynanthus superbus Clarke.METHODS Column chromatographic techniques were applied to isolate the constituents.EI-MS and NMR were used to identify the structures of the separated compounds.RESULTS Nine compounds were isolated from the methyl hydroxide extract of A.superbus,whose structures were elucidated as β-sitosterol(1),lupeol(2),carissol(3),3β-hydroxy-20(29)-lupen-28-oic acid(4),3-hydroxy-5,12-oleanadien-28-oic-acid(5),apigenin(6),5,7,4'-trihydroxy-6-methoxyflavone(7),ursolic acid(8) and β-daucosterol(9).CONCLUSION Compounds 1-9 are isolated for the first time from this plant.Compounds 2-7 are isolated for the first time from Gesneriaceae,and compounds 8-9 are isolated for the first time from the Aeschynanthus.

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OBJECTIVE To study the chemical constituents of Aeschynanthus superbus Clarke.METHODS Column chromatographic techniques were applied to isolate the constituents.EI-MS and NMR were used to identify the structures of the separated compounds.RESULTS Nine compounds were isolated from the methyl hydroxide extract of A.superbus,whose structures were elucidated as β-sitosterol(1),lupeol(2),carissol(3),3β-hydroxy-20(29)-lupen-28-oic acid(4),3-hydroxy-5,12-oleanadien-28-oic-acid(5),apigenin(6),5,7,4'-trihydroxy-6-methoxyflavone(7),ursolic acid(8) and β-daucosterol(9).CONCLUSION Compounds 1-9 are isolated for the first time from this plant.Compounds 2-7 are isolated for the first time from Gesneriaceae,and compounds 8-9 are isolated for the first time from the Aeschynanthus.

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Available abstract

OBJECTIVE To study the chemical constituents of Aeschynanthus superbus Clarke.METHODS Column chromatographic techniques were applied to isolate the constituents.EI-MS and NMR were used to identify the structures of the separated compounds.RESULTS Nine compounds were isolated from the methyl hydroxide extract of A.superbus,whose structures were elucidated as β-sitosterol(1),lupeol(2),carissol(3),3β-hydroxy-20(29)-lupen-28-oic acid(4),3-hydroxy-5,12-oleanadien-28-oic-acid(5),apigenin(6),5,7,4'-trihydroxy-6-methoxyflavone(7),ursolic acid(8) and β-daucosterol(9).CONCLUSION Compounds 1-9 are isolated for the first time from this plant.Compounds 2-7 are isolated for the first time from Gesneriaceae,and compounds 8-9 are isolated for the first time from the Aeschynanthus.

Key concepts: Ursolic acid, Lupeol, Chemical constituents, Chemistry, Gesneriaceae, Daucosterol, Chromatography, Traditional medicine

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