2011•Zhongguo xin yao zazhiRequires access
Effect of G004 on glucose and lipid metabolism in type 2 diabetic kkay mice
Wenping Zhang
Open publisher page 3 citations
Abstract
Objective: To investigate the effect of G004 on glucose and lipid metabolism in type 2 diabetic kkay mice.Methods: The effect of G004 on blood glucose,lipid and the hormones regulating blood glucose was examined in type 2 diabetic kkay mice.The insulin-secreting cell line β-TC-6 cells were used to examine its effect on stimulation of insulin secretion.Isolated rat pancreas was isolated and perfused with G004,and insulin concentrations in effluent perfusate were measured by radioimmunoassay(RIA).Results: The fasting plasma glucose,triglyceride level and free fatty acids levels were effectively reduced in kkay mice treated with G004.Insulin secretion was effectively promoted by G004 from the perfused pancreas and β-TC-6 cells.Conclusion: G004 stimulates insulin secretion and ameliorates the abnormity of glucose and lipid metabolism in kkay mice.