STUDY OF NPY、NT LEVEL IN HYPERTENSION AND THE ANTIHYPERTENSIVE MECHANISM OF BENALAPRIL

Objective:To investigate the actions of Neuropeptide Y(NPY) and Neurotensin(NT) in the development of essential hypertension(EH),and the possible antihypertensive mechanism of benalapril.Methods:Plasmic NPY and NT were measured with radioimmunoassay in 82 cases of hypertension and 42 normal controls.Results:There were significant difference of plasmic NPY and NT between hypertension patients and normal controls(P0 01) Plasmic NPY was negatively correlated with NT (r=-0.6514,P0 01).In reference with the ambulatory blood pressure monitoring ,NPY concentration remarkably increased and NT decreased significantly in patients with abnormal blood pressure rhythm compared with those with normal blood pressure rhythm.After 8 weeks′ treatment with Benalapril,NPY decreased and NT increased significantly in hypertensions.Conclusions: NPY and NT participated in the pathogenesis of hypertension.Benalapril could decrease blood pressure by decreasing NPY and increasing NT.