In-vitro antibacterial activity of different formulations of cefoperazone sodium/sulbacam sodium

Objective To evaluate the in-vitro antibacterial effect of different proportionment of cefoperazone sodium/sulbacam sodium(1 ∶ 0,4 ∶ 1,2 ∶ 1,1 ∶ 1) against common clinical isolates,so as to select the best ratio of cefoperazone and sulbactam in this compound. Methods The minimal inhibitory concentration(MIC) to the bacterial isolated from clinical department was measured by test tube dilution method. Used agar medium method to make the minimal bactericidal concentrations(MBC).Results The MIC and MBC of cefoperazone sodium/sulbactam sodium to pseudomona aeruginosa,escherichia coli and stophylococcus aureus,which were used with both standard bacterium and separate bacterium,were lower than that of only cefoperazone sodium.Conclusion The research result shows the antibacterial active of cefoperazone sodium/sulbactam sodium is better than that of cefoperazone sodium,it’s worth to extenting and useing.Under the same dosage of cefoperazone,the antibacterial active will boost up with increasing the dose of sulbactam sodium.